Air cooled engines on road vehicles are falling out of favor due to emissions. The temperature of the combustion chamber fluctuates more with an air cooled engine rather an a liquid cooled. More and more bikes are going to water cooling or oil-air cooling adn it's due to emissions and nothing else. Compared to the air cooled engines they replaced, with bikes the liquid cooled engine of comparable horsepower is heavier in weight, has the issue of finding a place to mount the radiator/s and is more complex when you consider the water pump, thermostat and such. They do tend to be quieter and don't have the fin ring (noise) some air cooled engines have.
As for coolant temp, the colder it is, the worse the fuel economy. I remember when 160 degrees was the norm, then 180, then 195 and now many are 205-210. The best fuel economy I ever got with my water cooled bike was on the 2007 trip. Ambient temperatures averaged 100-110F day after day and my bike was running hotter than a firecracker. I had to scrounge up a 3 ring binder, TV antenna, wire, nail and a rock to fashion a shroud to force more air into the radiator to keep the red light from going off. And with my air cooled bike, I could average 40-42 mpg day after day, but run in steady rain where the water cools the engine down and keeps it cool, mileage would routinely drop to 22-24 mpg. When the rain quit and the road dries, back to 40+.
As for air temp with normal coolant temps, back in the days of the 60 mph interstate speed limit, I would run my D150, 318, 2bbl and 3,21 axle to Chicago and back, a 820 mile round trip. I made that trip plenty of times and in the summer I'd average 17, in the winter 16 mpg year after year (figures were actual, corrected due to inaccurate speedo-odo). Just my experiences, although I must admit that I've always been kind of anal about keeping track of fuel consumption on any vehicle.